Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) _
                                                                    Handles Button2.Click
    Try
        Using conn As MySQLConnection = New MySQLConnection( _
                            New MySQLConnectionString("localhost", _
                                                      "test", _
                                                      "root", _
                                                      "", _
                                                      3306).AsString)
            conn.Open()
            Dim icmd As MySQLInsertCommand = New MySQLInsertCommand(conn, _
                            New Object(,) {{"field1", "111"}, _
                                           {"field2", "222"}, _
                                           {"field3", "333"}}, "mytest")
        End Using
    Catch ex As MySQLException
        MessageBox.Show(ex.Message, "MySQLエラー")
    Catch ex As Exception
        MessageBox.Show(ex.Message, "一般エラー")
    End Try
    MessageBox.Show("処理完了")
End Sub

mysql> use test;
Database changed
mysql> select * from mytest;
+--------+--------+--------+
| field1 | field2 | field3 |
+--------+--------+--------+
| 111    | 222    | 333    |
+--------+--------+--------+
1 rows in set (0.04 sec)